NEWPORT BEACH, Calif. – April 10, 2006 – The TriZetto Group, Inc. (Nasdaq:TZIX) today announced that it will hold a conference call to discuss its first quarter 2006 results on Tuesday, April 25, at 5:00 p.m. Eastern Time/2:00 p.m. Pacific Time. Investors are invited to join a live webcast of the call, which will be hosted by Chairman and CEO Jeff Margolis, President and COO Kathleen Earley, and CFO Jim Malone. A press release announcing the company's results will be issued prior to the call.

Investors may access the webcast through TriZetto's Web site at www.trizetto.com, first by clicking on the Investors button, then on the Company Information drop-down menu item, and then on Audio Presentations. The conference call will be archived and available through TriZetto's Web site for 30 days following the call.

The webcast will also be distributed over CCBN's Investor Distribution Network to both institutional and individual investors. Individual investors can listen to the call through CCBN's individual investor center at www.fulldisclosure.com or by visiting any of the investor sites in CCBN's Individual Investor Network. Institutional investors can access the call via CCBN's password-protected event management site, StreetEvents (www.streetevents.com).

CONTACTS:

Investors:
Brad Samson
949-719-2220
brad.samson@trizetto.com

Media:
Audrey McDill
303-495-7197
audrey.mcdill@trizetto.com