NEWPORT BEACH, Calif. – March 29, 2007 – The TriZetto Group Inc. (NASDAQ:TZIX) announced that Premera Blue Cross, which serves 1.3 million members in Alaska and Washington, has successfully gone live on TriZetto's Clinical CareAdvance(TM) software. The health plan is using Clinical CareAdvance to automate the continuum of member care, improve clinical staff productivity and extend the reach of its medical management programs. Clinical CareAdvance is one of two modules that comprise TriZetto's total CareAdvance Enterprise system, which automates all aspects of care management, enabling health plans to guide consumers on making better health decisions that can lower medical costs and improve health outcomes.

An open and highly flexible platform designed to work with various core administrative systems, Clinical CareAdvance integrates seamlessly with TriZetto's Facets® administrative system, which Premera has used since 2001. By automating manual processes and streamlining workflows, Clinical CareAdvance is helping Premera prioritize and route case management work according to rules established by the plan's clinical staff. Clinical CareAdvance also allows health plans to exchange information with multiple internal and external systems, such as Premera's predictive modeling software, resulting in a cohesive technology environment.

"Clinical CareAdvance gives us the functionality, ease of use, and flexibility we need to positively impact our case management operations," said John Castiglia, M.D., chief medical officer for Premera. "Our clinical staff is able to work more efficiently, with more members with critical needs than ever before. Ultimately, TriZetto's technology is helping us to boost internal productivity and improve the quality of care for our members."

Using Clinical CareAdvance, health plans can offer broad utilization, case and disease management, including automated member identification; guideline-based care planning; task management and assignments; ongoing member monitoring; and granular reporting. Importantly, Clinical CareAdvance involves members more directly in their health.

"With Clinical CareAdvance, health plans can perform all critical care management functions within one integrated application," said Gene Drabinski, president of TriZetto's Cost and Quality of Care unit. "TriZetto developed its advanced care management technology to help health plans meet the growing market demand for personalized member education and self-directed care management, especially with the rise of consumer retail healthcare."

About CareAdvance Enterprise

CareAdvance Enterprise is software that automates care management along the entire continuum of health, from the moment a member joins a plan, to when they leave the plan. The system includes two modules - Personal CareAdvance and Clinical CareAdvance - which integrate with the health plan's core information systems, aggregating the member's personal claims and diagnosis history, current prescriptions, and even laboratory data, into a single data repository. Members, their providers, and care managers can securely exchange and add information - at the member's discretion - via Internet browser, e-mail and other communication channels. By combining this data with an automated rules engine, the application enables health plans to send personalized information to members, including health risk assessments and reminders, secure messages, and customized health reports.

About Premera Blue Cross

Our mission is to provide peace of mind to our members about their health-care coverage. We provide health insurance and related services to more than 1.3 million people. Premera Blue Cross has operated in Washington since 1933, and Alaska since 1957. Premera Blue Cross is an independent licensee of the Blue Cross Blue Shield Association. Premera Blue Cross is a member of a family of companies based in Mountlake Terrace, Washington, that provide health, life, vision, dental, and long-term care insurance, and other related services.

About TriZetto

With its technology touching nearly half of the U.S. insured population, TriZetto is distinctly focused on accelerating the ability of healthcare payers to lead the industry's transformation to consumer-retail healthcare. The company provides premier information technology solutions that enhance its customers' revenue growth, increase their administrative efficiency and improve the cost and quality of care for their members. Healthcare payers include national and regional health insurance plans, and benefits administrators that provide transaction services to self-insured employer groups. The company's broad array of payer-focused information technology offerings include enterprise and component software, hosting and business process outsourcing services, and consulting. Headquartered in Newport Beach, Calif., TriZetto can be reached at 949-719-2200 or at www.trizetto.com.

Important Notice Regarding Forward-Looking Statements

This press release contains forward-looking statements that involve risks and uncertainties. The forward-looking statements are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. These forward-looking statements may include statements about future revenue, profits, cash flows and financial results, the market for TriZetto's and CareKey's services, future service offerings, industry trends, client and partner relationships, TriZetto's and CareKey's operational capabilities, future financial structure, uses of cash, acquisitions or proposed transactions. Actual results may differ materially from those stated in any forward-looking statements based on a number of factors, including the ability of TriZetto to successfully integrate the businesses of TriZetto and CareKey; the contributions of CareKey to TriZetto's operating results; the effectiveness of TriZetto's implementation of its business plan, the market's acceptance of TriZetto's new and existing products and services, the timing of new bookings, risks associated with management of growth, reliance on third parties to supply key components of TriZetto's and CareKey's services, attraction and retention of employees, variability of quarterly operating results, competitive factors, other risks associated with acquisitions, changes in demand for third party products or solutions which form the basis of TriZetto's service and product offerings, financial stability of TriZetto's and CareKey's customers, the ability of TriZetto and CareKey to meet their contractual obligations to customers, including service level and disaster recovery commitments, changes in government laws and regulations and risks associated with rapidly changing technology, as well as the other risks identified in TriZetto's SEC filings, including, but not limited to, its annual report on Form 10-K and quarterly reports on Form 10-Q, copies of which may be obtained by contacting TriZetto's Investor Relations department at 949-719-2225 or at TriZetto's web site at www.trizetto.com. All information in this release is as of March 29, 2007. TriZetto undertakes no duty to update any forward-looking statement to conform the statement to actual results or changes in the company's expectations.

CONTACTS:

Investor Contact:
Brad Samson
949-719-2220
brad.samson@trizetto.com

Media Contact:
Audrey McDill
303-495-7197
audrey.mcdill@trizetto.com